Pavel Afonine
Computational Research Scientist
Building: 33, Room 349
Mail Stop: 33R0345
Phone: (510) 221-7384
Fax: (510) 486-5909
PAfonine@lbl.gov
Links
Research Interests
1) New algorithms and methods development for crystallographic structure determination of small- and macro(bio)-molecules.
2) Software (Phenix) development for automated crystallographic structure solution, analysis and validation using X-ray, neutron and cryo-EM data.
3) Three-dimensional structure determination of macro-molecules.
Recent Publications
Related News
Cracking the Code: Using AI to Solve Difficult-to-map Proteins
Leveraging artificial intelligence and quantum calculations, scientists developed a new tool that yielded higher-quality structural information and solved notoriously elusive proteins.
Congratulations to Biosciences Area Director’s Award Recipients
Numerous Biosciences Area personnel are among the 2021 Berkeley Lab Director’s Awards honorees. This annual program recognizes outstanding contributions by employees to all facets of Lab activities. A complete list of winners can be found here. The 10th annual Director’s Awards ceremony will take place on November 18 at noon.
Revealing the Shapes of Molecular Machines
Within each cell of the human body, thousands of molecular machines are at work. They transport nutrients and biochemicals into and out of our cells, build other tiny machines, and even move our cells around. To understand how these molecular machines work, scientists create three-dimensional pictures using electron cryomicroscopy (cryo-EM), catching these machines in different shapes that give insight into their function. Now researchers at Berkeley Lab and their international collaborators who write and distribute the Phenix software suite have developed a new set of computational tools for automated structure determination from cryo-EM data.
