I head the Expression and Molecular Biology (EMB) Core under the directorship of Dr. Priscilla K. Cooper. My research has been an integral part of the SBDR Program Project, which is a multi-investigator, multi-institutional and interdisciplinary effort optimized to meet extreme challenges of characterizing transient and dynamic protein complexes and conformations that control the assembly and function of DNA repair machines. The EMB Core has served as a research, production and developmental resource for SBDR. My research team has efficiently incorporated advanced technologies and provided consistent, high quality key reagents (including vectors, proteins and cell products) and protein partnership information to jump-start Project and Program efforts. We have also attracted the greater scientific community to establish collaborations and gain access to our advanced cloning, expression and purification technologies for a wide variety of applications in basic, medical and biotechnological research.