Hiroshi Otani

Biologist Research Scientist

DOE Joint Genome Institute

Science Programs

Secondary Affiliation: Environmental Genomics and Systems Biology

Comparative and Functional Genomics

Building: 91, Room 250D1
Mail Stop: 91R0183
Phone: (510) 495-8541
hotani@lbl.gov

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Research Interests

My research focuses on secondary metabolism of microbes. I am particularly interested in understanding how the production of secondary metabolites is controlled and what their roles are.

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JGI Streamlines Regulon Identification in Bacteria

July 18, 2022

Using RIViT-seq technology, which combines an in vitro transcription assay with RNA sequencing, researchers identified the target genes of 11 sigma factors in Streptomyces coelicolor. The work, published in Nature Communications, was conducted by Joint Genome Institute (JGI) Director Nigel Mouncey and research scientist Hiroshi Otani. Both are members of the JGI’s Secondary Metabolite Science Program, which Mouncey leads. Transcription factors control when and how genes are turned on or off, making transcriptional regulation critical as it ensures those genes vital for growth and survival across various environments are expressed when their functions are needed. Learn more on the JGI website.

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