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A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to image smaller proteins and the crowded structures inside cells. (Credit: Credit: SayoStudio/Biohub) A woman and a man discuss equations written on a white board. People in a lab wearing white lab coats perform an experiment with a pipette and tray. Woman with dark hair wearing a lab coat standing in front of large-scale fermentation tanks.

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