In a Nature Communications report, a team of Berkeley Lab Biosciences Area scientists detail the first-ever successful use of a technique called BONCAT to isolate active microbes present in a sample of soil. Working within a Berkeley Lab-led scientific focus area called ENIGMA (for Ecosystems and Networks Integrated with Genes and Molecular Assemblies), Trent Northen’s lab in the Environmental Genomics and Systems Biology (EGSB) division teamed with JGI researchers on the work.
Blue Pigment from Engineered Fungi Could Help Turn the Textile Industry Green
Scientists at the Joint BioEnergy Institute developed a new biosynthetic production pathway which could provide a sustainable alternative to conventional synthetic blue dye. The highly efficient fungi-based platform may also open the door for producing many other valuable biological compounds that are currently very hard to manufacture.
Read more in the JBEI website.
A Vision for Team Bioscience
After more than two years of construction and a singular ribbon cutting, the Integrative Genomics Building (IGB) opened its doors for the first time to the staff who will soon call it home.
On June 19, Lawrence Berkeley National Laboratory (Berkeley Lab) celebrated the edifice with notable speakers articulating the vision for the building and its future inhabitants, before offering attendees a chance to tour the first floor.
“The reason for this building is a vision for integrating the Joint Genome Institute (JGI) and the Systems Biology Knowledgebase (KBase) into the main campus of the Laboratory,” said Berkeley Lab Director Michael Witherell. The two institutions, both funded by the Office of Biological and Environmental Research (BER) at the Department of Energy (DOE) Office of Science, have historically been off-site: JGI in Walnut Creek, about 18 miles away, and KBase at Aquatic Park.
Turning the Switch on Biofuels
Imidazolium ionic liquid (IIL) solvents are one of the best sources for extracting sugars from plants. But the sugars from IIL-treated biomass are inevitably contaminated with residual IILs that inhibit growth in bacteria and yeast, blocking biochemical production by these organisms.
Lawrence Livermore National Laboratory (LLNL) scientists and collaborators at the Joint BioEnergy Institute (JBEI) have identified a molecular mechanism in bacteria that can be manipulated to promote IIL tolerance, and therefore overcome a key gap in biofuel and biochemical production processes. The research appears in the Journal of Bacteriology.
Read more in the JBEI website.
X-ray Footprinting Reveals Molecular Basis of Orange Carotenoid Protein Photoprotection
Researchers at Berkeley Lab and Michigan State University (MSU), led by Corie Ralston and Cheryl Kerfeld, performed X-ray footprinting mass spectrometry (XFMS) experiments at the Advanced Light Source (ALS) beamline 5.3.1, which revealed new mechanistic details of the key events in orange carotenoid protein (OCP) photoprotection. XFMS is ideally suited to probing conformational dynamics at the single residue level, providing both a spatial and temporal view of site-specific changes in the OCP and its interaction with the fluorescence recovery protein (FRP). The experiments showed that FRP provides an extended binding region that holds the OCP together and forces proximity of the two domains that accelerate relaxation of OCP to its native state.
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