UC Berkeley researchers have created a new technique that can rapidly “print” two-dimensional arrays of cells and proteins that mimic a wide variety of cellular environments in the body. The technique could help scientists better understand the complex cell-to-cell messaging that dictates a cell’s final fate. David Schaffer, a faculty scientist in Molecular Biophysics and Integrated Bioimaging (MBIB), as well as a professor of chemical and biomolecular engineering at UC Berkeley, is co-senior author on the paper describing the work published in Science Advances.
Merchant Receives Moore Foundation Investigator Award
Sabeeha Merchant, faculty scientist in the Environmental Genomics and Systems Biology Division, has received an Investigator Award from the Gordon and Betty Moore Foundation. Merchant, who is also Professor of Biochemistry, Biophysics and Structural Biology and of Plant and Microbial Biology at UC Berkeley, will receive five years of unrestricted support to pursue innovative, risky research that has a high potential for significant conceptual and methodological advances in aquatic symbiosis.
The Biology Behind Your Love (or Hatred) of Coffee
New research by Paul Williams, staff scientist in the Molecular Biophysics & Integrated Bioimaging Division, suggests that our intake of coffee is affected by a positive feedback loop between genetics and the environment. This phenomenon, known as “quantile-specific heritability,” is also associated with cholesterol levels and body weight, and is thought to play a role in other human physiological and behavioral traits that defy simple explanation.
CRISPR Genome Editing Strategy Could Improve Rice, Other Crops
Scientists at UC Davis and collaborators at the Joint BioEnergy Institute (JBEI) have used CRISPR technology to genetically engineer rice with high levels of beta-carotene, the precursor of vitamin A. The technique they used provides a promising strategy for genetically improving rice and other crops. The study in Nature Communications was published by a research team led by Pam Ronald, a professor in the Genome Center and the Department of Plant Pathology at UC Davis and Scientific Lead of Plant Pathology at JBEI.
Biosciences Area 2020 LDRD Projects
The projects of 14 Biosciences Area scientists and engineers received funding through the FY20 Laboratory Directed Research and Development (LDRD) program. The funded projects span a diverse array of topics and approaches including: developing closed-loop plastics from biogenic feedstocks; reimagining a root system optimized for plant-microbe interactions; and creating computational tools for extracting macromolecular conformational dynamics. Lab-wide, 96 projects were selected from a field of 168 proposals. Biosciences Area efforts account for 18.5 percent of the $23 million allocated.
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