The Department of Energy has announced that eight distinguished scientists and engineers will receive the Ernest Orlando Lawrence Award, one of DOE’s highest honors. Named after Berkeley Lab’s founder, the award was established in 1959 and recognizes mid-career researchers for exceptional contributions supporting the DOE and its mission to advance the national, economic, and energy security of the United States.
Scientists Map Coronavirus Protein Linked to Immune Evasion, Disease Severity
A team of UC Berkeley and Berkeley Lab researchers used X-ray crystallography performed at the Advanced Light Source (ALS) to determine the atomic structure of ORF8, a protein secreted by the SARS-CoV-2 virus that is thought to help the pathogen evade and dampen response from human immune cells.
Unique X-Ray Microscope Reveals Dazzling 3D Cell Images
A team based at Berkeley Lab’s Advanced Light Source is making waves with its new approach for whole-cell visualization, using the world’s first soft X-ray tomography (SXT) microscope built for biological and biomedical research. In its latest study, published in Science Advances, the team used its platform to reveal never-before-seen details about insulin secretion in pancreatic cells taken from rats. This work was done in collaboration with a consortium of researchers dedicated to whole-cell modeling, called the Pancreatic β-Cell Consortium.
JGI’s CheckV Tool to Assess Virus Data Quality
Assembling viral genomes from metagenomes is challenging and often results in highly fragmented data, which limits the ability of researchers to accurately perform functional assessment, host prediction, and phylogenetic analysis. As reported in Nature Biotechnology, a team including JGI’s Stephen Nayfach, Frederik Schulz, Emiley Eloe-Fadrosh, Simon Roux and Nikos Kyrpides developed an automated tool called CheckV (pronounced “Check-Vee”) to help researchers assess and improve the quality of metagenome-assembled viral genomes. CheckV has already been applied to over 2.4 million viral genomes available in the latest release of IMG/VR, a database that is part of the Integrated Microbial Genomes & Microbiomes (IMG/M) suite. Learn more here on the JGI website.
JGI Launches Data Portal for Algae
A JGI team led by Algal Genomics Program lead Igor Grigoriev and data scientist Alan Kuo have unveiled PhycoCosm in the Nucleic Acids Research journal. The genome portal reinforces the JGI’s new strategic focus on exploring algal biology, diversity, and ecology. Read more here on the JGI website.
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