Scientists who specialize in studying the atom-by-atom choreography of enzymes have revealed new insights into the function of isopenicillin N synthase, an enzyme needed to produce some of the world’s most critical antibiotics.
AI-Fueled Software Reveals Accurate Protein Structure Prediction
For structural biologists who study proteins, predicting their shape offers a key to understanding their function and accelerating treatments for diseases like cancer and COVID-19. The current approaches to accurately mapping that shape have their limitations, but by applying powerful machine learning methods to the large library of protein structures it is now possible to predict a protein’s shape from its gene sequence.
CRISPR Voted Top Breakthrough at Berkeley Lab
In celebration of the Lab’s 90th anniversary, 16 of our most popular “90 Breakthroughs” faced off in the first ever Berkeley Lab Breakthroughs Bracket Challenge on Twitter. After four weeks of public voting online, the top breakthrough was “Created a Powerful Gene Editing Tool”—otherwise known as CRISPR!
JGI Helps Boost Small Molecule Production in Super ‘Soup’
Recently reported in Nature Communications, researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern University describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system. The work complements efforts to further develop sustainable alternative approaches for manufacturing bioproducts and biofuels. This is the first report of their work supported through the JGI’s Emerging Technologies Opportunity Program. Read the full story here on the JGI website.
ABPDU Celebrates a Decade of Bio-Innovation
Ten years ago, Lawrence Berkeley National Laboratory announced the opening of a brand new, 15,000-square-foot facility full of stainless steel state-of-the-art bioprocessing equipment – what we now know as the Advanced Biofuels and Bioproducts Process Development Unit, or ABPDU, was officially open for business.
Funded by the U.S. Department of Energy’s Bioenergy Technologies Office, ABPDU set out to provide a boost to the development of advanced biofuels – renewable fuels that produce at least 50% less greenhouse gas emissions than fossil fuels. ABPDU’s facility would serve as an industry-scale proving ground for biofuel discoveries made at lab bench-scale.
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