HCV harbors binding sites in its RNA genome for the liver-abundant microRNA, miR-122. This is the crystal structure of Ago2:miR-122 bound to HCV Site-1 RNA. Ago domains are colored grey-olive-gold, miR-122 in red, and HCV RNA in blue. Stem-loop 1 (SL1) extends from the center of the complex. (Figure 1f from article)