![Collage capturing a diverse set of bacteria and functions that can be better understood using DAP-seq. (Eduardo de Ugarte, Berkeley Lab)](https://biosciences.lbl.gov/wp-content/uploads/2021/12/wNatureMethods_EdU_v3-300x170.png)
One of the tools that researchers can apply to study the transcription factors that control how genes are turned on is known as DNA affinity purification sequencing or DAP-seq. The technology was developed by Ronan O’Malley, who leads the JGI Sequencing Technologies Group. In a Nature Methods article, JGI researchers led by co-first authors Leo Baumgart and Juna Lee developed two approaches that build upon the DAP-seq technology O’Malley developed. Read more here on the JGI website.