Continuing explorations into a remote hot spring, deep within the British Columbia backcountry, researchers from the University of Calgary and the JGI employed single-cell sequencing to assess the diversity within and between microbial populations. The work, published in The ISME Journal, showed the value of conducting large-scale single cell genomics by collecting nearly 500 single cells from a single low diversity hot spring sediment sample. Their work showed that single cell genomics can add significant value to the other commonly used culture-independent sequencing approaches including amplicon and metagenomic sequencing. Learn more here on the JGI website.