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JGI Develops “Hook and Bait” Single-Cell Genomic Approach to Bioprospecting

December 20, 2019

Graphical representation of the cellulose hook approach. (Devin Doud)
Graphical representation of the cellulose hook approach. (Devin Doud)

One of the most vital pieces of equipment for fly fishing is a boxful of lures. Designed with feathers or wires to mimic an insect or a particular movement, each of these lures are the bait designed to attract specific catches. A similar “hook and bait” technique has been developed by researchers led by JGI Microbial Program Head Tanja Woyke. Using a single-cell screen, they can now identify microbes with specific functional characteristics. When they tested the screen method on a microbial community from geothermal hot springs, they uncovered a novel cellulose-degrading bacterium typically found in low abundances. Read more on the JGI website.

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