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3-D Imaging Technique Maps Migration of DNA-carrying Material at the Center of Cells

November 17, 2016

This computer rendering shows the skeletonized structure of heterochromatinScientists in the Molecular Biophysics and Integrated Bioimaging Division (MBIB) have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture. A team of researchers, led by Carolyn Larabell, MBIB faculty scientist and professor at UCSF, Carolyn Larabellhave mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell using X-ray imaging tools in the National Center for X-ray Tomography at the Advanced Light Source. The results could help us understand how patterning and reorganization of DNA-containing material called chromatin in a cell’s nucleus relate to a cell’s specialized function as specific genes are activated or silenced. Read more at the Berkeley Lab News Center.

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