The work of Eva Nogales and Jennifer Doudna, Molecular Biophysics & Integrated Bioimaging Division faculty scientists, were highlighted in the August 18 Nature technology feature article, “Let the structural symphony begin,” a discussion of the current “golden time to do hybrid methodologies,” according to Nogales. Structural biologists, such as Nogales who was interviewed for this article, now have “the tools to tackle important questions about cells’ molecular machinery that would have been impossible to answer just a few years ago.” Combining these imaging methods – selecting from an impressive suite of different imaging techniques – is an increasingly popular approach in the field of structural biology, in which X-ray crystallography has been the premier method for more than a century. According to the article, while “the most powerful insights come from (these) hybrid methodologies that integrate images from several different tools,” it also has its drawbacks. Read the full article here.
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