Peter Zwart’s group at the Advanced Light Source (ALS), Beamline 5.0.2, a protein crystallography beamline that is part of the Berkeley Center for Structural Biology (BCSB), became the second ALS beamline to reach the 1,000 published structures mark. Proteins are the workhorses of biology, responsible for much of the architecture and chemistry of living cells. Knowing the crystal structure of a protein is the key to determining its function. The 1,000th published protein structure at 5.0.2 was a thiourea-containing anti-cancer agent. Beamline 8.3.1 became the first ALS beamline to pass the 1,000 published structure milestone earlier this year.