Corie Ralston

Biochemist Staff Scientist
Facility Director, Biological Nanostructures, Molecular Foundry

Molecular Biophysics and Integrated Bioimaging

Structural Biology

Building: 6, Room 2128
Mail Stop: 6R2100
Phone: (510) 495-2594
CYRalston@lbl.gov

Curriculum Vitae

Research Interests

Beamline instrumentation, macromolecular crystallography and X-ray footprinting technique development.

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Towards a New Framework for Radiation Cancer Treatment

February 7, 2024

Though it may seem counterintuitive, delivering ultrafast, high-intensity doses of radiation to tumors can actually reduce the toxicity to surrounding healthy cells, while still directing a potent anti-cancer effect towards the target. Scientists have documented this perplexing phenomenon—dubbed the FLASH radiotherapy effect—in both cell lines and animal models, but they have yet to confirm how or why it works. A new experimental platform that uses X-rays to investigate the FLASH effect brings science a step closer to clarifying its underlying mechanisms, laying the foundation for major strides in the field of radiation oncology.

Gemini Beamline Banks First Protein Structure

April 3, 2023

A protein structure obtained at Beamline 2.0.1 (“Gemini”) at the Advanced Light Source (ALS) has recently been published in the literature and deposited into the Protein Data Bank—two significant firsts for this beamline. The structure helped provide new insights into the molecular mechanisms involved in triggering certain inflammatory diseases. This milestone, which utilized Gemini’s capacity to target crystals smaller than 20 microns, was almost a decade in the making. Simon Morton, now a semi-retired staff scientist at ALS, and Corie Ralston, facility director at the Molecular Foundry and a staff scientist in the Molecular Biophysics and Integrated Bioimaging Division (MBIB), helped bring the microfocus beamline to the Berkeley Center for Structural Biology (BCSB) in 2014. Beamline operations are now led by Marc Allaire, a biophysicist staff scientist in MBIB and head of the BCSB.

Read More in the Berkeley Lab News Center.

Kerfeld to Lead New DOE-funded Center for Catalysis in Biomimetic Confinement

December 15, 2022

With $10.65 million in support from the U.S. Department of Energy (DOE), a new Energy Frontier Research Center based at Michigan State University (MSU) has been established. Led by Cheryl Kerfeld, a professor in the MSU-DOE Plant Research Laboratory, the Center for Catalysis in Biomimetic Confinement (CCBC) will explore how nature compartmentalizes some of its most important biochemical reactions.

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