Three Biosciences Area members were recently highlighted in the video series, Basics2Breakthroughs, which focuses on early career scientists discussing their research and what they hope for the future in that research.
The projects of 17 Biosciences Area scientists and engineers received funding through the FY22 Laboratory Directed Research and Development (LDRD) program.
A new approach to modifying microbes’ metabolic processes will speed up production of innovative bio-based fuels, materials, and chemicals
Researchers from Lawrence Berkeley National Laboratory (Berkeley Lab) have achieved unprecedented success in modifying a microbe to efficiently produce a compound of interest using a computational model and CRISPR-based gene editing.
Development of robust microbial platforms for bioproduction requires strains that have been engineered to have efficient carbon uptake, energy generation, tolerance to biomass pretreatment byproducts and the export of final product. Many of these optimizations require expression and overexpression of native and heterologous membrane proteins. Over the years, scientists at the U.S. Department of Energy’s Joint BioEnergy Institute (JBEI), and others have successfully found many such engineering targets. However, JBEI has also found that expression of membrane proteins is challenging and can also impact the microbial growth, thus negatively limiting the use of these discoveries. Read more from JBEI.