Molecular Biophysics and Integrated Bioimaging (MBIB) faculty scientist Markita Landry and Environmental Genomics and Systems Biology (EGSB) faculty scientist Niren Murthy are among the seven UC Berkeley faculty named to the 2019-20 cohort of Bakar Fellows. The UCB program fosters faculty entrepreneurship in fields including engineering, computer science, the biological and physical sciences, and architecture. The honor is bestowed on researchers with novel ideas and an entrepreneurial spirit, giving them the money and time to translate their laboratory breakthroughs into technologies ready for the marketplace.
Eva Nogales Named a 2020 Biophysical Society Fellow
Eva Nogales, a senior faculty scientist Molecular Biophysics and Integrated Bioimaging (MBIB), has been named a 2020 Fellow of the Biophysics Society. The international scientific society was created to promote the development and dissemination of biophysics knowledge through meetings, publications, community outreach, and career placement.
Nogales, who is also a Howard Hughes Medical Institute (HHMI) investigator and professor at UC Berkeley, is recognized for her demonstrated excellence in science and contributions to the success and vitality of the biophysics field. In addition, the society cited her efforts to push cryo-EM barriers and the resulting structural insights into the central dogma machinery and cytoskeleton interactions and dynamics in cell division, and her structural studies of microtubules and associated proteins, and of machineries regulating gene expression.
The awardees will be formally honored at the 2020 Annual Biophysical Society Meeting to be held in San Diego February 15–19.
Jennifer Doudna Awarded LUI Che Woo Prize
The Hong Kong-based LUI Che Woo Prize organization has named Jennifer Doudna one of three 2019 Prize for World Civilisation laureates. Doudna, a faculty scientist in Molecular Biophysics and Integrated Bioimaging (MBIB) professor of molecular and cell biology and of chemistry at UC Berkeley, was awarded the Welfare Betterment Prize for her pioneering discovery of CRISPR-Cas9 gene editing.
Established in 2015, the international award recognizes and honors an individual or organization contributing to sustainable development, the betterment of the welfare of humankind and the “promotion of positive life attitude and enhancement of positive energy,” according to the announcement. The prizes will be bestowed in a ceremony in Hong Kong on October 3. Each laureate will receive a certificate, a trophy, and a cash award equivalent to approximately 2.56 million U.S. dollars.
Read more in the UC Berkeley News Center.
UCB Study Finds Sleep May Be a Biomarker for Dementia
Research led by UC Berkeley scientists found that adults who reported a decline in sleep quality in midlife (40s–60s) had more beta amyloid and tau clusters in their brains—both of which are associated with a higher risk of developing dementia later in life. The same study also revealed that people with high levels of tau protein in their brains were more likely to lack the synchronized brain waves that are crucial to getting a good night’s sleep. Together, the findings suggest that sleep changes detectable in a simple overnight sleep study may serve as biomarkers for later risk of dementia.
X-ray Footprinting Reveals Molecular Basis of Orange Carotenoid Protein Photoprotection
Researchers at Berkeley Lab and Michigan State University (MSU), led by Corie Ralston and Cheryl Kerfeld, performed X-ray footprinting mass spectrometry (XFMS) experiments at the Advanced Light Source (ALS) beamline 5.3.1, which revealed new mechanistic details of the key events in orange carotenoid protein (OCP) photoprotection. XFMS is ideally suited to probing conformational dynamics at the single residue level, providing both a spatial and temporal view of site-specific changes in the OCP and its interaction with the fluorescence recovery protein (FRP). The experiments showed that FRP provides an extended binding region that holds the OCP together and forces proximity of the two domains that accelerate relaxation of OCP to its native state.
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