A team led by Harald Hess at the Howard Hughes Medical Institute (HHMI) Janelia Research Campus and Eric Betzig, a senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has devised a technique that combines cryogenic super-resolution fluorescence microscopy and focused ion beam–milling scanning electron microscopy. In a report in the journal Science, the researchers describe their technique, called cryo-SR/EM, and display some of exquisitely detailed three-dimensional images they captured of the complex innards of cells.
Jennifer Doudna Awarded 2020 Wolf Prize in Medicine
Jennifer Doudna, faculty scientist in the Molecular Biophysics & Integrated Bioimaging Division, will share the 2020 Wolf Prize in Medicine, a prestigious international prize awarded in Israel for unique contributions to humanity. Doudna, who is also UC Berkeley professor of molecular and cell biology and of chemistry, and colleague Emmanuelle Charpentier, director of the Max Planck Institute for Infection Biology in Berlin, Germany, were honored for their 2012 invention of the CRISPR-Cas9 gene-editing technology.
Cancer Drug Discovered with ALS Help Enters Phase 2 Trials
Seeking to develop a direct inhibitor of a mutant protein caused by errors in the KRAS gene, researchers at Amgen conducted X-ray crystallography of KRAS(G12C) proteins using the Berkeley Center for Structural Biology (BCSB) beamlines at the Advanced Light Source (ALS). The high-resolution structural maps generated from the data acquired revealed a small pocket on the molecule. Now, an investigational cancer drug that binds in this pocket will be evaluated in phase 2 clinical trials.
Cryo-EM Adapted to Visualize Atomic Structure of Synthetic Soft Material
Berkeley Lab scientists have demonstrated for the first time that cryogenic electron microscopy (cryo-EM), a Nobel Prize-winning technique originally designed to image proteins in solution, can be adapted to image atomic changes in a synthetic soft material.
Two from Biosciences Named AAAS Fellows
Two scientists from the Biosciences Area, Cheryl Kerfeld and David Schaffer, have been named Fellows of the American Association for the Advancement of Science (AAAS). They join fellow Lab scientists Rebecca Abergel in the Chemical Sciences Division, Roland Burgmann and Michael Manga in the Earth and Environmental Sciences Area Energy Geosciences Division, and Natalie Roe, Director of the Physics Division, in receiving the distinction of Fellow this year for “their scientifically or socially distinguished efforts to advance science or its applications.”
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