For the past several months, teams of bioscientists have utilized Berkeley Lab’s world-class research facilities to contribute to the national response to COVID-19, resulting in a wide range of promising research. Four videos showcase researcher contributions from across the Biosciences Area, which aim to help address some of the many scientific challenges posed by the pandemic.
MBIB Management Changes
Molecular Biophysics and Integrated Bioimaging (MBIB) Division Director Paul Adams has announced a number of changes in the Division leadership, effective July 21.
Building Blocks for COVID-19 Antiviral Drugs Identified in Rapid Study
Members of the UC San Francisco Quantitative Bioscience Institute Coronavirus Research Group (QCRG), in collaboration with Berkeley Lab and SLAC National Accelerator Laboratory (SLAC), have identified key chemical building blocks for an eventual antiviral drug against SARS-CoV-2, the virus that causes COVID-19. The newly identified compounds bind to an enzyme produced by the virus, called the “macro domain,” which is known to be crucial for the virus’s ability to replicate in human cells. The authors are writing up a formal manuscript describing the results for submission to a peer-reviewed academic journal, but also published their data directly online on July 1 to accelerate global efforts to fight the coronavirus pandemic.
Study Gains New Insight Into Bacterial DNA Packing
A Berkeley Lab-led team of researchers used multiple high-powered X-ray techniques at the Advanced Light Source to image the process in E. coli bacteria at the micro-, meso-, and nanoscales. The imaging technique they developed enabled them to visualize the bacteria’s chromosome at higher resolutions than ever before, and without the need for labeling, which slows down the process but is required by most other techniques.
James Holton Named ACA David J. Rognlie Award Winner
James Holton, a faculty scientist in the Molecular Biophysics and Bioimaging (MBIB) Division and full adjunct professor of biochemistry and biophysics at the University of California, San Francisco (UCSF), is the 2020 recipient of the American Crystallographic Association’s David J. Rognlie Award.
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