James Holton, a faculty scientist in the Molecular Biophysics and Bioimaging (MBIB) Division and full adjunct professor of biochemistry and biophysics at the University of California, San Francisco (UCSF), is the 2020 recipient of the American Crystallographic Association’s David J. Rognlie Award.
Finding the Missing Step of an Important Molecular Process
Lysine is an important amino acid that must be supplied in our diets, as our bodies can’t produce lysine on their own. Most cereal grains have low levels of lysine, and scientists have worked to breed crops with higher lysine levels.
However, the biochemical processes that break down lysine in plants weren’t fully understood. New Joint BioEnergy Institute (JBEI) research, published in Nature Communications, reveals this last missing step of lysine catabolism.
Enigmatic Protein Sculpts DNA to Repair Damage
Biosciences Area researchers and their collaborators have determined how a protein called XPG binds to and reshapes damaged DNA, illuminating its role in averting genetic disease and cancer.
Showtime for Photosynthesis
An international team led by researchers in Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging (MBIB) Division has revealed a key step in the molecular mechanism behind the water splitting reaction of photosynthesis. The finding could help inform the design of renewable energy technology.
X-ray Experiments Zero in on COVID-19 Antibodies
Data gathered at Berkeley Lab’s Advanced Light Source (ALS) by an international team of researchers indicate that antibodies derived from SARS survivors could potently block entry of SARS-CoV-2 and other closely related coronaviruses into host cells. Such antibodies could be used as a preventative treatment or as a post-exposure therapy.
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