Scientists at Berkeley Lab are working to expand our understanding of breast cancer diagnosis and treatment. Recently, a group in the BSE Division developed a framework that enables the transfer of discoveries derived from mouse models to humans. This success will allow breast cancer researchers to better predict how likely a tumor in humans is to metastasize based on how the corresponding cells in mice behaved.
Trio of Recent Studies Underscore Harms of Exposure to Thirdhand Smoke
The thirdhand smoke (THS) research group in Biosciences’ Biological Systems and Engineering (BSE) Division contributed to three recently-published studies that further underscore the harms of exposure to the lingering toxic residues from tobacco smoke.
Scientists Explore Links Between Genetics, Gut Microbiome, and Memory
A team of researchers from two U.S. Department of Energy national laboratories has found new evidence of tangible connections between the gut and the brain. The team, led by Antoine Snijders at Berkeley Lab and Janet Jansson at Pacific Northwest National Laboratory (PNNL), identified lactate—a molecule produced by all species of one gut microbe—as a key memory-boosting molecular messenger. The work was published in the journal BMC Microbiome.
Microbiome Signature Could Predict Post-op Enterocolitis in Hirschsprung Disease Patients
Biosciences Area researchers, in collaboration with colleagues at Nanjing Medical University in China, performed the first study to prospectively investigate the gut microbiome in relation to Hirschsprung-associated enterocolitis (HAEC), a leading cause of death in Hirschsprung disease patients. They identified a microbiome signature that might predict the development of postoperative HAEC. In addition, they found that exclusive breastfeeding might reduce the risk of HAEC through modulation of the intestinal microbiome.
New Round of Funding for Thirdhand Smoke Research
Berkeley Lab thirdhand smoke researchers have been awarded a new three-year grant totaling $904,744. The funding from the Tobacco-Related Disease Research Program (TRDRP) will support translational studies aimed at mitigating health impacts of exposure to thirdhand smoke (THS)—the toxic residues from tobacco smoke that linger on indoor surfaces and in dust long after a cigarette has been extinguished. From the Biosciences Area, Biological Systems and Engineering (BSE) Division staff scientist Bo Hang will serve as principal investigator on the studies, with senior scientist Jian-Hua Mao and staff scientist Antoine Snijders, also of BSE, as co-investigators. Collaborators on the project include staff scientist Hugo Destaillats and retiree affiliate Lara Gundel in the Energy Technologies Area (ETA) at Berkeley Lab, as well as researchers at California Consortium on Thirdhand Smoke partner institutions UC San Francisco and UC Riverside.
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