Reporter Mo Rocca explores “strokes of genius” in this episode. Among those he interviews is Jennifer Doudna, faculty scientist in the Molecular Biophysics and Integrated Bioimaging Division. The co-discoverer of the CRISPR gene-editing technology does not consider herself a genius, but rather thinks teams are more productive than individuals. Rocca also interviews internet pioneer Vint Cerf and musician Wynton Marsalis. Watch the episode.
Doudna Honored by National Academy of Sciences
Jennifer Doudna, faculty scientist in the Molecular Biophysics & Integrated Bioimaging Division, UC Berkeley professor of chemistry and of molecular and cell biology, and Howard Hughes Medical Institute investigator, will receive the 2018 National Academy of Sciences (NAS) Award in Chemical Sciences. According to the NAS award announcement, Doudna is honored for her “pioneering discoveries on how RNA can fold to function in complex ways,” and her invention, with Emmanuelle Charpentier, of “the technology for efficient site-specific genome engineering using the CRISPR/Cas9 nucleases for genome editing — a breakthrough technology which has had an immediate and wide impact on all areas of both basic and applied life sciences.”
Jennifer Doudna Talks CRISPR Origins, Implications with NPR’s Joe Palca
The Director’s Distinguished Women in Science Speaker Series at Berkeley Lab kicked off on Monday, November 20, with Jennifer Doudna, a faculty scientist in the Molecular Biophysics & Integrated Bioimaging (MBIB) Division, interviewed by NPR science correspondent Joe Palca. Doudna and Palca began the conversation by highlighting a common connection: They are both graduates of Pomona College in Southern California. From there, they covered a lot of ground, providing a vivid backdrop for the answer to the most pressing question of the day: How did Doudna discover the CRISPR/Cas9 genome editing tool?
CRISPR Target Recognition Mechanism Illuminated Using Data From ALS
Using diffraction data obtained at Berkeley Lab’s Advanced Light Source (ALS) and at the Stanford Synchrotron Radiation Lightsource (SSRL), researchers in Biosciences’ Molecular Biophysics & Integrated Bioimaging (MBIB) division and at UC Berkeley have discovered how CRISPR-associated (Cas) proteins are able to recognize their target locations with such great specificity. X-ray crystallography was used to solve the structures of Cas1 and Cas2—responsible for DNA-snippet capture and integration—as they were bound to synthesized DNA strands designed to mimic different stages of the process. The resulting structures show how the system works in its native context as part of a bacterial immune system, and also inform the development of the CRISPR-Cas system as a general-purpose molecular recording device. Jun-Jie Liu, a joint postdoc in the labs of Jennifer Doudna and Eva Nogales, and Addison Wright, a graduate student in Doudna’s lab, were co-first authors on the paper, published in the journal Science. Read more in this ALS Science Highlight.
Doudna Awarded Japan Prize for Invention of CRISPR Gene Editing
Jennifer Doudna and Emmanuelle Charpentier were awarded the 2017 Japan Prize in a press conference on February 2 by the Japan Prize Foundation, in Tokyo, for their roles in the development of the CRISPR-Cas9 gene-editing system, a revolutionary tool that promises cures for many heritable diseases. The Japan Prize is awarded annually to scientists and engineers from around the world who have made significant contributions to the advancement of science and technology, thereby furthering the cause of peace and prosperity of mankind.
According to the Foundation’s press release, Doudna, faculty scientist in the Molecular Biophysics & Integrated Bioimaging Division, UC Berkeley professor of chemistry and of molecular and cell biology, and Howard Hughes Medical Institute investigator; and Charpentier of the Max Planck Institute in Berlin were honored “for deciphering the molecular details of the type II bacterial immune system CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas and the creation of the CRISPR-Cas9 genome editing system, a truly revolutionary technique in genetic engineering, far more economical and faster than those previously available.” Read more at UC Berkeley News.
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