The projects of 22 Biosciences Area scientists and engineers received funding through the FY23 Laboratory Directed Research and Development (LDRD) program.
JGI Researchers Provide a Perspective on Giant Virus Diversity
In the last thirty years, in environments all over the world, scientists have discovered giants among viruses. Culturing studies have been key to understanding these viruses’ host range, morphological structures, and infection strategies. More recently, researchers have employed cultivation-independent approaches to discover thousands of new giant viruses, rapidly expanding the diversity of the Nucleocytoviricota phylum. A new review provides a perspective on giant virus diversity, and how sequencing and bioinformatics have sped up the study of giant viruses.
Biosciences Researchers Part of Genomic Analysis of Giant Bacteria Found in Guadeloupe Mangroves
In Science, a team led by Jean-Marie Volland, a scientist with joint appointments at the DOE Joint Genome Institute (JGI) and the Laboratory for Research in Complex Systems, and Silvina Gonzalez-Rizzo and Olivier Gros of the Université des Antilles, described the morphological and genomic features of a giant filamentous bacterium, along with its life cycle.
JGI’s CheckV Tool to Assess Virus Data Quality
Assembling viral genomes from metagenomes is challenging and often results in highly fragmented data, which limits the ability of researchers to accurately perform functional assessment, host prediction, and phylogenetic analysis. As reported in Nature Biotechnology, a team including JGI’s Stephen Nayfach, Frederik Schulz, Emiley Eloe-Fadrosh, Simon Roux and Nikos Kyrpides developed an automated tool called CheckV (pronounced “Check-Vee”) to help researchers assess and improve the quality of metagenome-assembled viral genomes. CheckV has already been applied to over 2.4 million viral genomes available in the latest release of IMG/VR, a database that is part of the Integrated Microbial Genomes & Microbiomes (IMG/M) suite. Learn more here on the JGI website.
JGI Team Describes Host-Virus Dynamics In a Microbial Mat
Previous work on microbial mats had primarily relied on culturing virus and host pairs in the laboratory to study their interactions. In The ISME Journal, a team co-led by JGI postdoctoral researcher Mária Džunková used single-cell sequencing to sequence both a cell’s genome and detect accompanying viral sequences, which would suggest the virus had been infecting the cell. Read the full story on the JGI website.
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