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Study featured on the cover of the January 18, 2023 issue of Cell Reports Physical Science. (Courtesy of Cell Press) Agustin Avila-Sakar A composite image of the enzyme lactase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. (Credit: Veronica Falconieri/National Cancer Institute) A new microscopy technique combines electron microscopy and light microscopy to generate detailed, three-dimensional images of cells. Credit: D. Hoffman et al./Science 2020 cryo-EM polypeptoid sheets

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