Yiwen Zhu

Biologist Research Scientist

Environmental Genomics and Systems Biology

Comparative and Functional Genomics

Building: 84, Room 238
Mail Stop: 84R0171
Phone: (510) 495-2300
Fax: (510) 486-4229
yzhu@lbl.gov

Research Interests

• Studying genes or non-coding DNA and enhancers and their functional significance in mammalian gene regulation and diseases using targeted knock-out, knock-in or transgenic mouse models via in vivo CRISPR/Cas9 genome editing.
• Understanding the functional necessity of enhancers, noncoding sequences that activate gene expression using single-cell transcriptomics tools (DropSeq 10X Chromium Single cell and Chromium Single Cell ATAC technologies).

Selected Publications
Selected Publications

ResearchGate Profile

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Technique for Studying Gene Expression Takes Root in Plants

May 16, 2019

Researchers led by Diane Dickel have successfully adapted an open-source RNA analysis platform to study gene expression in individual plant cells. The method, called Drop-seq, was developed at Harvard Medical School in 2015 and had previously been used only in animal cells. Dickel and her colleagues at the DOE Joint Genome Institute (JGI) teamed up with researchers from UC Davis who had perfected a protoplasting technique for root tissue from Arabidopsis thaliana (mouse-ear cress). After preparing samples of more than 12,000 Arabidopsis root cells, the group was thrilled when the Drop-seq process went smoother than expected. Their results were published in Cell Reports.

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