Biological Faculty Engineer
Molecular Biophysics and Integrated Bioimaging
- Structural Biology
Building: Stanley Hall, Room 208A
Mail Stop: 1762
Phone: (510) 643-8165
My research program is focused on understanding the molecular basis of cell mechanics and mechanotransduction with them aim to shed light on the role of these biological processes in human disease. Our specific attention is on the role of two macromolecular systems in cellular function, namely the integrin-mediated focal adhesions at the interface between the cell and extracellular matrix (ECM) and the nuclear pore complex (NPC). Focal adhesions are the immediate sites of cell interaction with the ECM, and as such they play a key role in mechanosensing and mechanotransduction at the edge of the cell. Nuclear pores could also play a role in the overall process of cellular mechanotransduction by exquisitely controlling the material transport in and out of the nucleus, thereby regulating the gene expression and protein synthesis.