Biosciences Area

  • About Biosciences
    • Leadership
    • Area Operations Centers
    • Strategic Plan and Reports
    • Strategic Programs Development Group
    • Contact Information
  • Our Science
    • Area Programs
    • Strategic Initiatives
    • Biological Systems and Engineering
    • Environmental Genomics and Systems Biology
    • Molecular Biophysics and Integrated Bioimaging
    • DOE Joint Genome Institute
  • Media and Events
    • News
    • Announcements
    • Behind the Breakthroughs
    • Events Calendar
    • Seminar Series
  • Staff Resources
    • Commonly Used Acronyms
    • Communications
    • Hiring and Recruitment
    • Hybrid & Telework Resources
    • IDEA
    • Intellectual Property, Industry Engagement, and Entrepreneurship
    • LDRD Information
    • Logos and Templates
    • Mentoring Program
  • Search

John A. Tainer

Visiting Faculty
Professor, The University of Texas MD Anderson Cancer Center

Molecular Biophysics and Integrated Bioimaging

  • Structural Biology

Building: 33, Room 0238B
Phone: (510) 486-4158
Fax: (510) 486-6880
JATainer@lbl.gov

Programs & Initiatives

The SIBYLS Beamline

Research Interests

We focus on structural biology methods and applications for analysis and design projects that concern fundamental questions of molecular cell biology and biochemistry relevant to biological mechanisms and human disease.

DNA damage responses provide master keys to unlock oncogenic synthetic lethality and activate innate immunity for cancer biology and medicine going forward. Our research focuses on applying structural biochemistry and biophysics to molecular and cellular oncology and cancer biology for predictive molecular mechanisms and innovative strategies that target DNA damage responses in cancer. By solving and building upon >350 macromolecular structures, our group is developing and applying methods for integrating X-ray and cryo-EM data to build quantitative and foundational knowledge resulting in publications and patents aimed at advanced patient care.

 

LinkedIn Profile
ResearchGate Profile

Was this page useful?

Send
like not like

Enigmatic Protein Sculpts DNA to Repair Damage

June 23, 2020

Biosciences Area researchers and their collaborators have determined how a protein called XPG binds to and reshapes damaged DNA, illuminating its role in averting genetic disease and cancer.

Programming Proteins to Pair Perfectly

January 4, 2019

Bioscientists at the Advanced Light Source (ALS) at Berkeley Lab lent their expertise to a project led by scientists at the University of Washington to design proteins in the lab that zip together like DNA. The technique could enable the design of protein nanomachines to help diagnose and treat disease, allow for more precise engineering of cells, and perform a variety of other tasks.

Strong Biosciences Presence at East Bay STEM Career Awareness Day

April 26, 2018

Claire Robertson (Bissell Lab) The 7th Annual East Bay STEM Career Awareness Day took place on April 26 at Wareham Development’s Aquatic Park Center in West Berkeley, home to Biosciences Operations @ Berkeley and several Area research groups. The event, organized by the Institute for STEM Education housed at California State University East Bay, had support from Berkeley Lab and several East Bay-based businesses.

For more John A. Tainer news items »

About Biosciences

  • Leadership
  • Area Operations Centers
  • Inclusion, Diversity, Equity, and Accountability (IDEA)
  • Contact

Divisions & User Facility

  • Biological Systems and Engineering
  • Environmental Genomics and Systems Biology
  • Molecular Biophysics and Integrated Bioimaging
  • DOE Joint Genome Institute

Resources

  • A-Z Index
  • Phonebook
  • Logos
  • Acronyms
  • Integrated Safety Management
Questions & Comments
Follow us: Mastodon LinkedIn YouTube