Hoi-Ying Holman

Director of Berkeley Synchrotron Infrared Structural Biology Program
Chemist Senior Scientist

Molecular Biophysics and Integrated Bioimaging

Cellular and Tissue Imaging

Building: 70A, Room 3317L
Mail Stop: 70A-3317
Phone: (510) 486-5943
Fax: (510) 486-7152
HYHolman@lbl.gov
https://bsisb.lbl.gov/wordpress/

Curriculum Vitae

Research Interests

Hoi-Ying’s research interests are in microbial ecology, geomicrobiology, bioenergy, bioremediation, and bioavailability of chemicals to ecological receptors. As a Director of the Berkeley Synchrotron Infrared Structural Biology (BSISB) imaging program at the Advanced Light Source (ALS), she focuses on developing and providing research communities new synchrotron infrared (SIR) technologies for deciphering the relationship between genome and functional processes, and identifying the connection between the genome and natural environments. She and her team, Sun Choi, Liang Chen, and Giovanni Birarda, were awarded a 2014 R&D 100 award for their development of the Berkeley Lab Multiplex Chemotyping Microarray (MCM). Current technologies in active development in the BSISB program are: SIR nano-spectroscopy, SIR plasmon resonance microscopy, and the integration of SIR spectromicroscopy with ambient IR laser ablation (AIRLAB) mass spectrometry.

Selected Publications

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Automating Scientific Discoveries

July 28, 2021

As instruments in large-scale user facilities are becoming more powerful, the volume of data and its complexity also grow. To leverage these heightened capabilities and accelerate scientific discoveries, a field known as autonomous discovery has emerged. It uses algorithms to learn from a comparatively little amount of input data and determine the best next experimental steps — all with minimal human intervention.

To Speed Discovery, Infrared Microscopy Goes ‘Off the Grid’

February 24, 2021

Researchers from Berkeley Lab, UC Berkeley, and Caltech devised a more efficient way to collect “high-dimensional” infrared images, where each pixel contains rich physical and chemical information. The new technique, implemented at the Advanced Light Source’s (ALS) infrared beamline 1.4, uses a grid-less, adaptive approach that autonomously increases sampling in areas displaying greater physical or chemical contrast. With the new method, scans that would’ve taken up to 10 hours to complete can now be done in under an hour.

Focusing in on Aquatic Microbes: Berkeley Lab Scientists Receive Grant for New Microscopy Approach

October 14, 2020

The Gordon and Betty Moore Foundation is supporting the development of a unique microscopy concept pioneered by researchers at Berkeley Lab as part of the Foundation’s Symbiosis in Aquatic Systems Initiative (SASI). The Berkeley Lab effort has received $500,000 and will be led by senior staff scientist Hoi-Ying Holman of the Molecular Biophysics and Integrated Bioimaging (MBIB) Division.