cryo-EM, biochemistry, complex biological assemblies, structure and regulation of the cytoskeleton, microtubule dynamics, human transcriptional initiation machinery, epigenetics, gene silencing, biophysics
Eva Nogales is a senior faculty scientist, Professor of Biochemistry, Biophysics and Structural Biology, and a Howard Hughes Investigator. The Nogales Lab is dedicated to gaining mechanistic insight into crucial molecular processes in the life of the eukaryotic cell. Their two main research themes are the dynamic self-assembly of cytoskeleton during its essential functions in cell division, and the molecular machines governing the regulation of gene expression, specially at the transcriptional level. The unifying principle in their work is the emphasis on studying macromolecular assemblies as whole units of molecular function by direct visualization of their architecture, functional states and regulatory interactions. With this overall aim in mind they use electron microscopy and image analysis, complemented with biochemical and biophysical assays, towards a molecular understanding of their systems of interest.