Research Interests

Professor Schepartz’s research group is interested in questions that span the chemistry-biology continuum. We seek to establish new knowledge about the chemistry of complex cellular processes and apply this knowledge to design or discover molecules–both small and large–with unique or useful properties. We apply the tools of organic synthesis, biochemistry, biophysics, and structural, molecular, and synthetic biology in our work. Current projects focus on (1) repurposing the ribosome to biosynthesize sequence-defined chemical polymers and polyketides; (2) exploring and improving novel tools for trafficking proteins to the cytosol and nucleus for therapeutic applications; (3) understanding the mechanism by which chemical information is transported through cellular membranes; and (4) developing new probes and fluorophores to image organelle dynamics at super-resolution for highly extended times and in multiple colors.

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