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CRISPR-Cas13 creates an evolutionary bottleneck by targeting the RNA of diverse phages, allowing for edited phages (orange) to be specifically enriched. (Credit: Davian Ho) Abstract image of gold lights and squares against a black backdrop The cover of Nature Reviews Microbiology, with an illustration of a giant virus in purple. Open book with circular representations of microbial genomes above, all against a green background a green fern against a black background A digital illustration inspired by methane-eating archaea and the Borgs that assimilate them (Credit: Jenny Nuss/Berkeley Lab)

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