The Biosciences Area’s Nathalie Elisabeth and Jean-Marie Volland collaborated on a study led by researchers from Cornell that produced the first full genome of a species of giant bacteria. Members of the Epulopiscium genus, the largest known heterotrophic bacteria, are a million times larger than E. coli. They live in the guts of tropical marine fish, an environment rich in sodium, which the team’s analysis suggests the bacteria use, along with polysaccharides from their host’s diet, to meet their outsize energy requirements.
Rising Sea Levels Could Mean Higher Wetlands Methane Emissions
Area researchers led a team that examined the microbial, chemical, and geological features of 11 wetland zones in the Bay Area. Their findings indicate that the factors governing how much greenhouse gas is stored or emitted in natural landscapes are more complex and difficult to predict than previously thought.
Researchers Assess AlphaFold Model Accuracy
An international team of researchers that included developers of the Phenix software suite performed an analysis of AlphaFold predictions, comparing them with both high-quality experimental data and experimentally determined structures. Their results led them to conclude that AI-based protein structure predictions are best considered to be exceptionally useful hypotheses, and that experimental measurements remain essential for confirmation of the details of protein structures.
Barcoding Bacteriophages
A team led by Environmental Genomics and Systems Biology (EGSB) staff scientist Vivek Mutalik demonstrated for the first time that they can, on a genome-wide scale, identify phage genes that are essential (or not) to infecting bacteria, and then replace non-essential DNA with distinctive barcode tags. These barcodes could enable investigators and clinicians to quickly identify and track different phages in diverse settings, similar to how product barcodes are used in supermarkets. Brought to scale, the method stands to unlock potent biotechnology applications relevant to agriculture, the environment, human health, and more.
Ning Sun Featured in Mushroom Documentary
ABPDU research scientist Ning Sun is featured in a Matador Network documentary on how mushrooms can play a role in reducing carbon emissions and creating new sustainable materials. Sun discusses ABPDU’s work with industry characterizing mycelium grown leather material.
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