A new project co-led by Environmental Genomics and Systems Biology Division scientist Christopher Mungall has received a $10 million five-year grant from the National Institutes of Health to establish a Center of Excellence in Genomic Science (CEGS). An international, multi-institutional collaboration, the new center will develop tools to modernize how biomedical information about genetic conditions is captured, stored, and exchanged.
New Algorithm Sharpens Focus of World’s Most Powerful Microscopes
In recent years, cryo-electron microscopy (cryo-EM) technology has advanced to the point that it can produce structures with atomic-level resolution for many types of molecules. Yet in some situations, even the most sophisticated cryo-EM methods still generate maps with lower resolution and greater uncertainty than required to tease out the details of complex chemical reactions.
In a study published in Nature Methods, a multi-institutional team led by Tom Terwilliger from the New Mexico Consortium and including researchers from Berkeley Lab demonstrates how a new computer algorithm improves the quality of the 3D molecular structure maps generated with cryo-EM.
It’s All Connected: Your Genes, Your Environment, and Your Health
Statistician Paul Williams, a staff scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, specializes in investigating the instances where genetics and environment are most closely intertwined. His work focuses on a phenomenon called “quantile-dependent expressivity,” which describes the relationship between the genes that predispose people to certain traits that can be amplified by behavior and environmental factors.
Study Finds ‘Missing Link’ in the Evolutionary History of Carbon-Fixing Protein Rubisco
In a study appearing in Nature Plants, researchers from UC Davis, UC Berkeley, and Berkeley Lab report the discovery and characterization of a previously undescribed lineage of form I rubisco – one that the researchers suspect diverged from form I rubisco prior to the evolution of cyanobacteria. The novel lineage, called form I’ rubisco, gives researchers new insights into the structural evolution of form I rubisco, potentially providing clues as to how this enzyme changed the planet.
The work was led by Patrick Shih, a UC Davis assistant professor and the director of Plant Biosystems Design at the Joint BioEnergy Institute (JBEI), and Doug Banda, a postdoctoral scholar in his lab.
Plant Single-cell Solutions for Energy and the Environment Workshop Report Released
On January 23, 2020, Berkeley Lab hosted a workshop on opportunities afforded by single-cell technologies for energy and environmental science, as well as conceptual and technological grand challenges that must be tackled to apply these powerful approaches to plants, fungi and algae. This event, which was spearheaded by Diane Dickel in the Environmental Genomics and Systems Biology Division, brought together a diverse group of leaders in functional genomics technologies from academia, the National Laboratories, and local research institutions.
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