In Nature, a team led by researchers at the University of Texas at Austin, the HudsonAlpha Institute for Biotechnology, and DOE Joint Genome Institute has produced a high-quality reference sequence of the complex switchgrass genome. Building off this work, researchers at all four DOE Bioenergy Research Centers—the Great Lakes Bioenergy Research Center, the Center for … Read more »
Inhalable COVID-19 Protection via Synthetic Nanobodies
Using protein structures obtained in part at the Advanced Light Source (ALS), researchers from the University of California San Francisco (UCSF) produced simplified antibodies (“nanobodies”) engineered to be highly effective at blocking SARS-CoV-2, the virus that causes COVID-19. Because they are extremely stable, these nanobodies can be aerosolized, stored at room temperature, and self-administered as needed, directly to affected nasal or lung tissues using nasal sprays or inhalers.
To Find Mutated Sperm, Go FISH
Chemotherapy and radiation treatments can be life-saving for patients with cancer, but they have harsh side effects that can been felt and seen throughout the body. There can also be unseen consequences: These important treatments can mutate DNA and damage chromosomes in patients’ cancerous and noncancerous cells alike. When this occurs in a germline cell (eggs in women and sperm in men), it can lead to serious fetal and birth defects in a resulting pregnancy. In a study published in PLOS One, a team led by Biological Systems and Engineering (BSE) Division senior scientist Andrew Wyrobek reported success adapting an established cellular DNA analysis technique called fluorescence in situ hybridization (FISH) to probe sperm DNA for a wide variety of chromosomal defects simultaneously.
Sussing Out Sorghum Cell Wall Structure
Sorghum is a promising bioenergy crop. However, the thick secondary cell walls of the stems of this plant are difficult to break down into components that could become fuel. Recent research led by the Joint BioEnergy Institute on structural details of specific molecules and their interactions in sorghum grass cell walls suggests ways to ease deconstruction of this bioenergy crop.
Shine On: Avalanching Nanoparticles Break Barriers to Imaging Cells in Real Time
The diffraction limit is a fundamental property of light that has long prevented optical microscopes from bringing into focus anything smaller than half the wavelength of visible light (~200 nanometers), which is at least an order of magnitude larger than the tiny protein machines that keep cells, and us, running. A team of researchers co-led scientists in Berkeley Lab’s Molecular Foundry and Columbia University’s school of engineering developed a new class of crystalline material that, when used as a microscopic probe, overcomes the diffraction limit without heavy computation or a super-resolution microscope. The amazing new material, called avalanching nanoparticles (ANPs), will advance high-resolution, real-time bio-imaging of a cell’s organelles and proteins, as well as the development of ultrasensitive optical sensors and neuromorphic computing that mimics the neural structure of the human brain, among other applications. The work was reported in a cover article in the journal Nature.
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