Using Berkeley Center for Structural Biology (BCSB) beamline 5.0.1, researchers from Gilead Sciences investigated a promising small-molecule drug, GS‑6207, that they developed to inhibit replication of the human immunodeficiency virus (HIV).
Jennifer Doudna and the Nobel Prize: The Advanced Light Source Perspective
Emmanuelle Charpentier and Jennifer Doudna winning the 2020 Nobel Prize for Chemistry for their development of the CRISPR method of genome editing is a momentous achievement, supported by the contributions of numerous individuals and institutions, including the Advanced Light Source (ALS) synchrotron user facility at Berkeley Lab. This feature details how Doudna’s research was enabled by the facility’s early embrace of hard X-ray crystallography technology for atomic-level understanding of molecular structure, as well as her use of the Berkeley Center for Structural Biology’s (BCSB’s) wiggler-based beamline 5.0.2 for macromolecular crystallography. Doudna has published some 35 papers using ALS crystallography beamlines, including two cited by the Nobel Committee in its CRISPR-Cas9 scientific background document.
ABPDU’s Open Source Software Benefits Biotech Community
Bioreactors are at the heart of biomanufacturing. These vessels help scientists understand how their technologies perform and how to scale them up. However, transferring processes between bioreactors is often difficult. The U.S. Department of Energy’s Bioenergy Technologies Office’s Advanced Biofuels and Bioproducts Process Development Unit (ABPDU) at Lawrence Berkeley National Laboratory received this feedback from their collaborators, who suggested that ABPDU create a set of tools that would make these processes easier.
Chasing Their Tails But Getting Somewhere: Reimagining the Shape of Noise Leads to Improved Molecular Models
Elliot Perryman, a computer science and physics major at the University of Tennessee, began working with staff scientist Peter Zwart in the Center for Advanced Mathematics for Energy Research Applications (CAMERA) last fall through the Berkeley Lab Undergraduate Research (BLUR) program. Together they developed an algorithm that will extract better structures from low-quality crystallographic diffraction data.
JBEI’s Pamela Ronald Named GCHERA World Agriculture Prize Laureate
Pamela Ronald, the Joint BioEnergy Institute’s (JBEI) Scientific Lead for Plant Pathology in the Feedstocks division, has been named the 2020 World Agriculture Prize laureate by the Global Confederation of Higher Education Associations for Agricultural and Life Sciences, or GCHERA. Ronald is a distinguished professor in the Department of Plant Pathology at the University of California, Davis (one of JBEI’s six academic research partners) and with the UC Davis Genome Center. She becomes the first woman whose work is recognized by the award. The virtual award ceremony will be held on November 30.
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