A team led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has produced the first detailed 3D structure of human SAGA, a 20-piece molecular machine that’s crucial to life. The structure, reported in Nature Structural & Molecular Biology, revealed some unexpected differences between the human and yeast versions of SAGA and could guide the development of drugs to treat diseases that arise when this complex malfunctions.
JGI Enables Time-series Study of ‘The Blob’s’ Impact
Enabled by the JGI’s Community Science Program, a team led by University of British Columbia researchers tracked the impact of a large-scale heatwave event in the ocean known as “The Blob.” The microbial communities in the ocean drive the biological pump that takes carbon from the atmosphere and keeps it in the deep ocean. With genomic samples collected before, during and after The Blob, the researchers developed a preliminary model of how marine microbial communities are affected by warming events. They recently shared their findings in Communications Biology. The work underscores the value of large-scale research collaborations and of conducting even more time-series studies.
Learn more here on the JGI website.
JGI Helps Reveal Marine Microbe Contains Multitudes
The bacterium SAR324 is unusually cosmopolitan. In the ocean’s North Pacific Subtropical Gyre, microbes tend to stay localized at different depths. But SAR324 can be found throughout the water column, from the warm, well-lit surface, to the blue-lit twilight zone, to the continuous pressure of the dark abyss, 4000 m (2.5 miles) deep. Scientists have wondered, how can SAR324 exist in so many varied environments? Now, a recent study supported by JGI and has uncovered that SAR324 encompasses four subgroups, adapted to different oceanic depths and relying on different ways of living. Read more about the hidden diversity of SAR324 on the JGI website.
JGI Part of Berkeley Lab Team Receiving HPCwire Award in Life Sciences
At SC21, the HPCwire Editors Choice Award for Best Use of HPC in Life Sciences went to the Berkeley Lab team comprised of JGI and ExaBiome Project team, supported by the DOE Exascale Computing Project. The award recognized the release of MetaHipMer, an end-to-end genome assembler that supports “an unprecendented assembly of environmental microbiomes.
“They produced fantastic scientific results this year by assembling a collection of large datasets that will enable scientists to explore and collect data in new ways,” said JGI Chief Informatics Officer Kjiersten Fagnan of the award. “We’re excited to be able to offer this capability to the JGI user community moving forward and to assemble, for the first time these large environmental microbial data sets for JGI users, which include projects looking at wildfire impacts, carbon cycling, and the microbial dynamics in freshwater lakes over a several year period.”
Nogales Appointed to Royal Academy of Spain
Eva Nogales, a senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, was appointed as a foreign member attached to the Natural Sciences Section of the Royal Academy of Exact, Physical, and Natural Sciences of Spain. The Royal Academy, founded in 1847, is tasked with promoting study and research in the mathematical, physical, chemical, geological, and biological sciences, as well as disseminating the knowledge gained thereby. It is made up of a maximum of 72 permanent members, 144 corresponding members, and supernumerary members and foreign members. Nogales, who is also a Howard Hughes Medical Institute (HHMI) investigator and professor at UC Berkeley, obtained her bachelor’s degree in physics from the Universidad Autonoma de Madrid in Spain. Her research specialty involves using electron microscopy (EM) and image analysis, as well as biochemical and biophysical assays to gain mechanistic insights into crucial molecular processes in the life of eukaryotic cells.
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