Using RIViT-seq technology, which combines an in vitro transcription assay with RNA sequencing, researchers identified the target genes of 11 sigma factors in Streptomyces coelicolor. The work, published in Nature Communications, was conducted by Joint Genome Institute (JGI) Director Nigel Mouncey and research scientist Hiroshi Otani. Both are members of the JGI’s Secondary Metabolite Science Program, which Mouncey leads. Transcription factors control when and how genes are turned on or off, making transcriptional regulation critical as it ensures those genes vital for growth and survival across various environments are expressed when their functions are needed. Learn more on the JGI website.
An Old Tube Holds Key To 30 Year Protein Structure Mystery
After decades of failed attempts, scientists have solved the structure of a protein domain at the center of several major diseases using Berkeley Center for Structural Biology’s beamline 5.0.2.
Simulations at NERSC Reveal Origins of Brain Electrical Signals
The origin of the electrical signals recorded at the brain’s surface by electrocorticography (ECoG) has long remained a mystery. Kris Bouchard, a staff scientist in the Biological Systems and Engineering (BSE) Division, led a seven-year research effort to understand precisely which neurons are generating the recorded signals.
Bacteria for Blastoff: Using Microbes to Make Supercharged New Rocket Fuel
A group of biofuel experts led by Berkeley Lab took inspiration from an extraordinary antifungal molecule made by Streptomyces bacteria to develop a totally new type of fuel that has projected energy density greater than the most advanced heavy-duty fuels used today, including the rocket fuels used by NASA.
Biosciences Researchers Part of Genomic Analysis of Giant Bacteria Found in Guadeloupe Mangroves
In Science, a team led by Jean-Marie Volland, a scientist with joint appointments at the DOE Joint Genome Institute (JGI) and the Laboratory for Research in Complex Systems, and Silvina Gonzalez-Rizzo and Olivier Gros of the Université des Antilles, described the morphological and genomic features of a giant filamentous bacterium, along with its life cycle.
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