Using RIViT-seq technology, which combines an in vitro transcription assay with RNA sequencing, researchers identified the target genes of 11 sigma factors in Streptomyces coelicolor. The work, published in Nature Communications, was conducted by Joint Genome Institute (JGI) Director Nigel Mouncey and research scientist Hiroshi Otani. Both are members of the JGI’s Secondary Metabolite Science Program, which Mouncey leads. Transcription factors control when and how genes are turned on or off, making transcriptional regulation critical as it ensures those genes vital for growth and survival across various environments are expressed when their functions are needed. Learn more on the JGI website.
In Science, a team led by Jean-Marie Volland, a scientist with joint appointments at the DOE Joint Genome Institute (JGI) and the Laboratory for Research in Complex Systems, and Silvina Gonzalez-Rizzo and Olivier Gros of the Université des Antilles, described the morphological and genomic features of a giant filamentous bacterium, along with its life cycle.More »
In Nature Ecology and Evolution, researchers from the Chinese Academy of Fishery Sciences, the University of East Anglia, and the JGI have explored the genome of the polar algae Microglena sp. YARC. The green alga harbors extra genes for proteins requiring zinc, and those genes turn out to be key for the phytoplankton’s ability to live in cold polar waters. Learn more here on the JGI website.More »
Biosciences Area staff recently hosted 40 PhD students from Wageningen University in the Netherlands over two days at Emery Station East (ESE) and the Integrative Genomics Building (IGB). The group launched their two-week California tour in the Bay Area, stopping by local biotechnology companies and prominent academic research institutions. The contingent visited ESE to tour the facility, make presentations, and discuss potential collaborations. At the IGB, the students attended a day-long symposium that included short talks, tours of several user facilities, and a poster reception.More »
The biopolymer has far-reaching potential from medical therapeutics to replacing synthetic plastics. Armed with a deep understanding of how the enzymes makes acholetin, scientists now have a target for preventing bacterial contamination and the means to produce acholetin for a variety of purposes.More »