Bioscientists at the Advanced Light Source (ALS) at Berkeley Lab lent their expertise to a project led by scientists at the University of Washington to design proteins in the lab that zip together like DNA. The technique could enable the design of protein nanomachines to help diagnose and treat disease, allow for more precise engineering of cells, and perform a variety of other tasks.
The National Institutes of Health (NIH) has awarded $9.3 million to Berkeley Lab to support ongoing development of PHENIX, a software suite for solving three-dimensional macromolecular structures. Officially launched in 2000, the project is a collaboration among researchers based at Berkeley Lab, Los Alamos National Laboratory, Cambridge University, and Duke University. “The impetus behind PHENIX is a desire to make the computational aspects of crystallography more automated, reducing human error and speeding solutions,” said PHENIX principal investigator Paul Adams, director of Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging Division (MBIB). Read more from the Berkeley Lab News Center.
Research led by Cheryl Kerfeld, with members of her group in Berkeley Lab Biosciences’ Molecular Biophysics and Integrated Bioimaging (MBIB) Division, as well as her MSU-DOE Plant Research group at Michigan State University, has identified and characterized a new, functionally distinct member of the Orange Carotenoid Protein (OCP) family. The OCP complex enables chromatically acclimating blue-green algae to avoid cellular damage and growth inhibition in conditions of high light or nutrient stress.