Steven E. Brenner

Biologist Faculty Scientist

Environmental Genomics and Systems Biology

Biosystems Data Science

Building: 927, Room 461A
Mail Stop: KOSHLAND
Phone: (510) 643-9131
Fax: (510) 666-2505
SEBrenner@lbl.gov
http://compbio.berkeley.edu/

Research Interests

The Brenner research lab has three key research interests involving computational and experimental genomics: individual genome interpretation, gene regulation by alternative splicing and nonsense-mediated mRNA decay, and prediction of protein function using Bayesian phylogenomics.

Selected Publications

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From a Single Genetic Mutation, Secrets of ‘Boy in the Bubble’ Disease Revealed

February 12, 2017

Steven Brenner, a biologist faculty scientist in the Environmental Genomics & Systems Biology Division and a UC Berkeley computational biologist, was part of an interdisciplinary, international research team that has identified the rare genetic mutation responsible for a unique case of “boy in the bubble” disease, known as severe combined immunodeficiency (SCID), a deadly immune system disorder. The researchers found that the cause was a mutated version of a gene called BCL11B, which also plays an unexpected role in the normal processes of immune system development.

“This is a gene that had never been associated with SCID before, which required more advanced genome analysis techniques to discover,” said Brenner, co-author of the study, published on December 1 in the New England Journal of Medicine. “Moreover, unlike variants in every other known SCID gene, this mutation is dominant, which means you only need one copy of this mutation to disrupt multiple aspects of development.” Read more at UC Berkeley News.

Brenner Named ISCB Fellow 2016

March 2, 2016

Steven E. Brenner, faculty biologist in the Environmental Genomics & Systems Biology Division and Professor, Department of Plant and Microbial Biology at the University of California, Berkeley, has been conferred with Fellow status in the International Society for Computational Biology (ISCB). Fellows are ISCB members who have distinguished themselves through exceptional contributions to the fields of computational biology and bioinformatics. Brenner was recognized for his significant research contributions to protein analysis and genetics, and notable organizational service to the field, especially through Critical Assessment of Genome Interpretation (CAGI) and DREAM competitions. Brenner is one of thirteen Fellows selected for this year’s class, which will be introduced at Intelligent Systems for Molecular Biology 2016 in Orlando, Florida, in July.

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