Research Interests

Our current research focuses on the development of next-generation microscopy and spectroscopy tools to address pressing questions in cell biology. We developed a new method to enable electron microscopy, and correlated super-resolution microscopy, of fully hydrated animal cells by employing graphene, a single-atom-thick carbon meshwork, as the thinnest possible impermeable and conductive membrane to protect cells from vacuum. We also recently introduced and realized the new concept of spectrally resolved, “true-color” super-resolution microscopy, in which we synchronously obtain the fluorescence spectra and positions of millions of single molecules in densely labeled cell samples in minutes. Based on this approach, we have demonstrated in our work high-quality multicolor 3D super-resolution microscopy for 4 dyes only 10 nm separated in emission wavelength.

Selected Publications