Research Interests

• Protein structure
• Bioenergetic membranes
• Cellular organisation
• Electron cryo tomography 

Using electron cryo-tomography with sub-tomogram averaging together with single particle electron cryo-microscopy, we aim to determining how the structure and organization of proteins in situ influence cellular structure and function. My lab focuses on understanding the biogenesis of bioenergetic compartments and how the structure of these compartments changes with changing environmental conditions such as light, temperature and nutrient availability.

Current projects:

• Role of ATP synthase in shaping mitochondrial cristae
• Role of NADH and NADPH dehydrogenases in carbon fixation
• Assembly of carboxysomes
• Deciphering target specificity and lethality mechanism of phage-like particles

Cryo-Electron Microscopy Equipment at LBNL:
• Jeol 3200 with in column energy filter and K2 camera
• JEOL-1400 Flash
• 1 Vitrobot
• Cryo-CLEM system Leica
• Cryo-microtome
• Microtome
• Three carbon coaters
• Glow discharge machine

Cryo-Electron Microscope Equipment at UCB
Two Titan Krios with post column energy filter and K3 camera (QB3/HHMI)
Artica with K3 camera (QB3)
Bal-tec HPM-010 high pressure freezer (EML)

Selected Publications

ResearchGate Profile