Research Interests

We focus on structural biology methods and applications for analysis and design projects that concern fundamental questions of molecular cell biology and biochemistry relevant to biological mechanisms and human disease.

DNA damage responses provide master keys to unlock oncogenic synthetic lethality and activate innate immunity for cancer biology and medicine going forward. Our research focuses on applying structural biochemistry and biophysics to molecular and cellular oncology and cancer biology for predictive molecular mechanisms and innovative strategies that target DNA damage responses in cancer. By solving and building upon >350 macromolecular structures, our group is developing and applying methods for integrating X-ray and cryo-EM data to build quantitative and foundational knowledge resulting in publications and patents aimed at advanced patient care.

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