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A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryogenic electron microscope’s contrast, allowing biologists to image smaller proteins and the crowded structures inside cells. (Credit: SayoStudio/Biohub) Photo showing three potato plants growing in soil: the ones on the left and right are healthy; the one in the middle is wilted due to the bacterium Ralstonia solanacearum. A pale-skinned woman with a silver bob wearing a black blazer over a blue blouse stands near a laboratory bench holding a 3D molecular model.

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