My research interests focus on the development of advanced imaging systems and techniques for biological research as well as for clinical applications. This includes developing advanced instrumentation for applications in medical imaging and homeland security, specifically developing advanced detector technologies and electronics to improve the performance and capability of radiation imaging detectors used in positron emission tomography (PET), single photon emission computed tomography (SPECT), and x-ray computed tomography (CT) systems. My current research areas focus on the development of: (1) novel photodetectors and radiation detectors, (2) custom integrated circuits and electronics, and (3) new detector design and camera geometries. Currently, I have a project developing an open, flexible, scalable, and high-performance electronics system for applications in radionuclide imaging called OpenPET. In addition, I am developing a novel photon-counting detector technology to improve the imaging performance of conventional x-ray imaging system as well as to transform it into a functional imaging platform. Another research area that I am investigating is developing advanced PET detector module that has excellent timing performance to enable the benefits of time-of-flight PET as well as providing a solution for developing advanced multimodality imaging systems. My research is primarily supported by the National Institute of Health.