Reporter Mo Rocca explores “strokes of genius” in this episode. Among those he interviews is Jennifer Doudna, faculty scientist in the Molecular Biophysics and Integrated Bioimaging Division. The co-discoverer of the CRISPR gene-editing technology does not consider herself a genius, but rather thinks teams are more productive than individuals. Rocca also interviews internet pioneer Vint Cerf and musician Wynton Marsalis. Watch the episode.
Reported March 19, 2018, in Nature Biotechnology, an international team including JGI scientists presents one of the largest targeted cultivation and sequencing projects to date: a reference catalog of rumen microbial genomes and isolates cultivated and sequenced from the Hungate1000 collection. The catalog was produced through the coordinated efforts of rumen microbiology researchers worldwide. At the beginning of the project, there were only reference genomes for 14 bacteria and one methanogen. The Hungate catalog now contains a total of 501 genomes—410 newly generated from this study, plus an additional 91 already publicly available from other studies. Read the full story on the JGI website.
Susan Marqusee, faculty scientist in the Molecular Biophysics and Integrated Bioimaging Division, will receive the Dorothy Crowfoot Hodgkin Award, sponsored by Genentech, which is granted in recognition of exceptional contributions in protein science that profoundly influence our understanding of biology. Marqusee, a biophysical chemist whose work focuses on protein folding and dynamics, is one of the world’s top experimental scientists in the field of protein folding.More »
Associate Laboratory Director for Biosciences Mary Maxon testified on March 14 to the US House of Representatives committee with leaders from four other national laboratories on “National Laboratories: World-Leading Innovation in Science.” Maxon pointed to the flexibility and breadth of the national laboratories to respond to national mission needs, through national user facilities, scientific research expertise, and partnering with universities and industry. The full testimony can be found here. (Maxon’s testimony begins at 43:22 of the video.)
The Kv7 family of voltage-gated potassium channels control excitability in the heart, brain, and ear, and harbor mutations associated with arrhythmias, epilepsy, and deafness. A recent study, led by Molecular Biophysics and Integrated Bioimaging (MBIB) faculty scientist Daniel Minor’s group in the Cardiovascular Research Institute at UCSF, used both diffraction and scattering beamlines of ALS-ENABLE to reveal a universal switch mechanism by which the calcium sensor protein calmodulin controls the action of these channels. The findings, reported in the journal Neuron, provide a key link between Kv7 channel activity and cellular signaling pathways. Greg Hura, a research scientist in MBIB, was also a co-author on the paper. Watch a video detailing the work.