Regulation of the enzyme telomerase has been implicated in cancer, other human diseases, and aging, but progress towards therapeutic manipulation of telomerase has been hampered by the lack of high-resolution structural data. Now, researchers in senior faculty scientist Eva Nogales’ lab in Molecular Biophysics and Integrated Bioimaging (MBIB), in collaboration with UC Berkeley professor of Biochemistry, Biophysics and Structural Biology Kathleen Collins, have published a paper in Nature describing the 3-D molecular structure of the human telomerase enzyme.More »
The projects of 13 Biosciences Area scientists and engineers received funding through the FY18 Laboratory Directed Research and Development (LDRD) program. These projects span a diverse array of topics and approaches including the study of microbiomes in relation to patterns of mutualism, crop productivity, and gut health; synthetic biology for engineering biosurfactant production and energy conversion pathways; and the application of technologies such as machine learning, high-resolution optical microscopy, and single-cell transcriptomics. Together, these efforts account for 18.75 percent of the $20 million allocated. Lab-wide, 74 projects were selected from a field of 215.More »
Two proposals, from Biosciences Area researchers Cynthia McMurray and Carolyn Larabell, have been recommended for funding by the Chan Zuckerberg Initiative (CZI) through a new grant program focused on developing collaborative computational tools to support the Human Cell Atlas (HCA). A global endeavor governed by an organizing committee co-chaired by Aviv Regev at the Broad Institute of MIT and Harvard and Sarah Teichmann at the Wellcome Trust Sanger Institute, the HCA will generate a variety of molecular and imaging data across a range of modalities and spatial scales. To advance the analysis, interpretation, and dissemination of these data, the CZI issued an open call in July 2017 for proposals aimed at creating new computational tools, algorithms, visualizations, and benchmark datasets. After a thorough evaluation process, CZI recommended 85 projects (out of nearly 300 submissions) for funding, and will provide $15 million in total over one year for their execution.More »
“The key design principle of natural photosynthesis is the closing of the photosynthetic cycle on the shortest possible length scale under membrane separation of the incompatible water oxidation and proton reduction environments,” said Heinz Frei, a senior scientist in Biosciences’ Molecular Biophysics and Integrated Bioimaging (MBIB) Division. With collaborators Eran Edri, a former postdoctoral fellow in MBIB now at Ben-Gurion University, and Shaul Aloni in the Molecular Foundry Division, Frei developed a fabrication method to make a square-inch sized artificial photosystem, in the form of an inorganic core-shell nanotube array, that implements this design principle for the first time. The method was described in a paper published earlier this year in ACS Nano.More »
Marking its 10th anniversary this year, the Women Scientists & Engineers Council (WSEC) is about to embark on a new set of initiatives to make the Lab an even better place to work, from partnering with HR on the development of new training opportunities, to exploring ways to improve communication around maternity leave for new hires.
Several Biosciences staff members are active in WSEC namely MBIB’s Jill Fuss, Work-Life Balance subcommittee, JGI’s Esther Singer, Empowerment subcommittee co-chair Esther Singer and Biosciences’ Astrid Terry, Networking subcommittee co-chair.
Read more in Today At Berkeley Lab.