Researchers at the Joint BioEnergy Institute (JBEI) and the Advanced Biofuels & Bioproducts Process Development Unit (ABPDU), part of the Biological Systems and Engineering (BSE) Division, have developed a new polyketide synthase-based platform and prototyped efficient production of potential biofuels, gasoline additives, and commodity chemicals.More »
While much is known about how enzymes and molecules are involved in cellular respiration, the understanding of the respiration system as a whole remains limited. Researchers at the Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have gained insight into how cellular respiration is affected by the membrane environment in which it occurs. By engineering lipid synthesis to carefully control the membrane composition, researchers found that lipids, which consist of fatty acid molecules and determine membrane viscosity, also tightly control the rate of bacterial and yeast respiration. As lipid synthesis in these hosts is often engineered in order to produce molecules, these findings suggest new ways by which the pathways to produce biofuels and bioproducts could be optimized to maintain proper respiratory function, thereby increasing production. For more, read the JBEI news story.
Two teams of Biosciences Area researchers are representing Berkeley Lab as part of cohort eight of the U.S. Department of Energy’s I-Corps program, an intensive two-month training course that pairs national laboratory researchers with industry mentors to develop viable market pathways for their technologies. The teams, led by Deepti Tanjore and Esther Singer, presented their projects during the opening session held October 1–5 in Golden, Colorado.More »
When studying human cells in a laboratory, it is important that the media, or the broth that bathes the cells, contains all of the nutrients necessary to support cells through their normal growth and division phases even though they are outside of the body. Bioscientists at Berkeley Lab have a long history of studying breast cancer, and Martha Stampfer, senior scientist in the Biological Systems & Engineering (BSE) Division, has spent decades developing media now widely used by the community. Today, PLOS ONE published a study describing a comprehensive analysis of three kinds of media used to grow human mammary epithelial cells (HMEC).More »
On September 20-21, JBEI hosted an internal workshop that covered the fundamentals of the production of petroleum and natural gas and their refining and conversion to chemicals. The workshop leader was Dr. Paul Bryan, former Director of DOE’s Bioenergy Technology Office (BETO), and the former VP of Biofuels Technology and Founding Manager of the Alliance for Advanced Energy Solutions for Chevron.More »